Hacker News new | past | comments | ask | show | jobs | submit login

Look up creatine as a candidate treatment for sleep deprivation.



Creatine plus exercise. I add 1.5 tsp to my morning tea, plus 1/5 tsp NAD and 1/2 tsp of L-theanine, and I've doubled my workout and no longer have DOMS. It's like I'm a teenager again.

I tried it because I'd been getting 4-5 hours of broken sleep due to peripheral neuropathy from a congenital spinal disorder for the past four or five years, and I finally feel like I'm healing. It's wild being able to fall asleep and stay asleep.


Are there long term studies on the effects of creatine? I was asking given the evidence for increased cancer, and mortality associated with high red meat intake, but a lack of understanding re the causative mechanisms.


I think mouse feed is probably the healthiest diet according to mouse models.


Do you only take it in the days you exercise? Does it have any side effects?


Creatine is one of the very few supplements that seems to have only upsides and few if any side effects (except the basically obligatory "minor stomach upsets for some people" ). You can take it every day at any time of day, the effects take a few weeks to build up.

The main downside is that the effects are small - most of the research is in strength and endurance training and it seems like at most there's a 5-10% increase in lifting endurance (IIRC, it's been a while since I researched this).

It's one of a very few supplements that I personally feel should be generally taken by most people (unless you eat a lot of red meat).

The others are omega 3 (unless you eat fish several times a week) and possibly magnesium as the western diet tends to be low in that.

If you want to read more about effects of creatine on the brain this is a good paper:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916590/

The consensus seems to be that supplementation of creatine is less clearly linked to increases in the brain than it is for muscle (although there have only been limited studies done), however, if you've ever suffered from depression, sleep deprivation or other neurological issues it's likely to be beneficial. For people without those issues, there's less evidence yet, but they would still get the benefit of more energy overall if not specifically more cognitive energy.


Creatine is awesome, but hair loss in men with male pattern baldness is frequently reported by myself and others in comments under all the "creatine is amazing no downsides" youtube posts and elsewhere. I've experienced it personally.


Is it temporary? Does hair loss go away when you stop taking creatine?


It could be that men who feel the need to start taking creatine are at the point in life where baldness is likely to occur, are taking other supplements that could be testosterone converting, are exploring these options as part of an unconscious recognition of an onset of balding, or are just becoming aware of existing balding due to greater self-awareness due to their self-improvement.

I'd put any one of those ahead of "creatine made me go bald".


The link to baldness comes indirectly through increasing DHT. The increase in DHT, if I understand right, can speed up existing hair loss. Where it gets shaky is that DHT is also increased by excersize and follow-up studies accounting for that found a decrease in DHT while on creatine. So we don’t know yet, basically, and you should stop if there is a concern.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7871530/


It did for me.


The caveat is finding a high-quality supply of creatine. So many on-line reviews for once great brands of creatine powder talk about how those brands recently switched to a new supplier, how the consistency changed to that of powdered sugar, and how all of a sudden they were getting major gastrointestinal problems from a brand that used to be good.

It's hard to know where to go for the right kind of supplement. I've taken it as an exercise supplement in the past with no seeming downsides, but in a few hours search, I couldn't find a supply that doesn't have dozens to hundreds of these complaints against it.


Are there any high-quality suppliers you can recommend?


Kre-Alkyn on Amazon has a patented method of getting it past the stomach acid which I’ve found, over many, years, removes the bloating issues with monohydrate (most common)


> and few if any side effects

I don't know your dosage and use case but under creatine loading (5+ grams/die), water weight and bloating becomes a very, very noticeable side effect (in responders).


afaik that's temporary and lasts only a few weeks, even if maintaining the loading dose. The effect also seems localized to muscles so unless you are overweight the effect is mostly flattering.


It Is indeed, but carrying extra water Kgs becomes immediately noticeable during the first hill climb.


I know someone who got painful kidney stones from Creatine. Pretty scared of taking it now


I know someone who got painful kidney stones and didn’t take any creatine. Pretty scared of not taking it now


Look up the link between Creatine and kidney stones before blindly dismissing it.


Is Vitamin D's omission from your list deliberate?


I originally put it in, along with vitamin c during flu season, but felt I haven't personally done enough research to make claims about them. Regarding vitamin d, I am unsure about whether it should be taken with vitamin k or not.


With K2 to counteract the risk of soft tissue calcification.


It’s a common deficiency especially in the winter, but most people don’t benefit from regular supplements.

At least assuming 20ng/mL is a reasonable minimum. Some people suggest that’s a little low, but there’s real issues with excess vitamin D.


So take k2 with your d3


Everyday. It's retained in skeletal muscle, so I consider it similar to carb loading on off days. I exercise at least lightly every morning and get around 5 miles in a day. My biggest struggle is being diligent about getting enough protein and calories.

From everything I've read, creatine is as close to being a "free benefit" as it gets. I didn't experience any overt improvement just from taking it, as in, no extra energy or motivation. However, I'd stalled on all of my exercises for about a year, and after a week of "loading" 10g/day, I started back and instantly hit my max reps in a single set. I didn't want to hurt myself and was scared of DOMS, so I waited another week before trying again (I had a single day of soreness). After a light warmup, I immediately did it again. The results of that have been highly motivating, and I've remained excited to push myself.

The only side effect is that I enjoy my tea slightly less. Creatine doesn't have a flavor, but it makes everything taste 20% less delicious, somehow.


You need to be drinking more water while taking creatine. This is important to point out because the side effects of not getting enough water are very rough and taking creatine can put you there faster.


it does, but only for some. for me it causes massive muscle cramps, no matter how much water I drink.

other then that, creatine is considered the only supplement (protein not considered a supplement) that has virtually no side effects and known gain.

caffeine is behind that with some side effects.

beyond that, most other supplements havent been either to have proven benefits and proven no side effects


I‘m taking creatine every day, and think it’s great for various reasons. Do you think it has an affect on sleep quality itself, or does it just improve things during the day?


I personally find that sleep quality does drop a bit but I also don’t need as much every night. The sleep-tracking apps I use say the opposite though, that quality is much higher and I get more hours in. It’s a bit of a different flavour of sleep maybe, that the apps aren’t tuned for.


Can you point to any good research to back up your claim that this is a good treatment?


I liked this one https://www.nature.com/articles/s41598-024-54249-9

They went with the premise of "a little a day seems to help, what happens if we feed ridiculous quantities once". The sort of medical research that appeals to the engineer in me and something you can only really do with compounds that are already known to be unlikely to kill your patient if you exceed the usual dose. Also I strongly suspect they did this to students given the age range.

There's more literature out there than this. That paper's references are probably a reasonable start point. But as creatine is very cheap and has been widely consumed by athletes for ages now it's about as low risk a gamble as any out there.




Guidelines | FAQ | Lists | API | Security | Legal | Apply to YC | Contact

Search: