If I remember correctly, one of his answers was something like "Because it's the only Universe where we could ask such a question". I think what he means is that all the other possible universes (or most of them) might or might not exist somewhere else, but they certainly don't include intelligent life with the ability to ask "Why is there something instead of nothing?". When you ask that question you are assuming this is the only universe and it was "meant to be". But our sole existence is not evidence at all for a "destination".
"What do I do now" is a complete different question, and I guess people might find their own personal answers in the most varied places. You obviously don't need a physicist for that, although lots of them also think about these things.
I doubt we'll ever get the answer to the first one in this life/physical realm. Philosophy can help ponder over the second one though.