This really depends on where you draw the line between knowledge and non knowledge. Our entirety scientific body is the best explanation we have for the phenomenon we as a social species have observed. Much of what we call 'knowledge' - like maths or physics, is actually human produced culture (in that it is taught after it has been discovered). It is subject to being incorrect (although it would take a very powerful set of observations, deductions, definitions, and measurements to prove it incorrect).

I think honestly, the line between nature and nurture really depends on what you believe makes you human, conscious, and existing with awareness. You can technically define the entire existence of the universe as a process of changing states of information (some of which may not be measurable).