I've had a similar thought RE using Route53 for Neocities. Here's the problem with Route53 though. If you get a DDoS attack using it, it's quite plausible that you would be charged for resources used in the DDoS attack. A recent Vice article discussed this: http://motherboard.vice.com/read/inside-the-unending-cyber-s...
DDoS is a nasty problem. We've received a DDoS attack that shut the entire site down for days. We can't use Cloudflare because they don't support wildcard domains without their very expensive plan. I've also heard stories from people using Cloudflare that have still not been able to resolve DDoS issues (I'm not knocking Cloudflare, they're a great company that does a really good job fighting this very hard problem, but sometimes even they have trouble with it).
I'll be completely honest and say that I have no idea how to solve this problem. It's really, really, really hard. Switching to different service providers won't get you very far against the monster DDoS attacks that some people can execute.
If you're going to go the Amazon route then you absolutely need to keep an eye on billing, and set up alerts so that any DDoS which caused a spike in your costs would be caught as soon as possible.
I was burnt by this in the first 48 hours of using Amazon DNS. Very unlucky I guess... I'm amazed they still bill for DDOS traffic, or even traffic from black-listed IPs. It seems many of their competitors don't.
DDoS is a nasty problem. We've received a DDoS attack that shut the entire site down for days. We can't use Cloudflare because they don't support wildcard domains without their very expensive plan. I've also heard stories from people using Cloudflare that have still not been able to resolve DDoS issues (I'm not knocking Cloudflare, they're a great company that does a really good job fighting this very hard problem, but sometimes even they have trouble with it).
I'll be completely honest and say that I have no idea how to solve this problem. It's really, really, really hard. Switching to different service providers won't get you very far against the monster DDoS attacks that some people can execute.