That is a major plot point in Spider Robinson's Callahan's Con. (Look, his first few Callahan stories were charmingly quirky, and I got into the habit of reading them. This is not an endorsement of his larger oeuvre, okay?) In that case, the cosmic microwave background was used as the inertial reference, probabilities were the main problem to solve (we'd be well beyond the relative simplicity of the three-body problem), and little details like delta-v were not merely hand-waved away.