A lot of people still have blinders on and can't see past the imaging problems to the exascale analysis that's required to exploit these data, or just view the computational side as perfunctory and don't anticipate that it will likely end up being just as challenging, from a research and economic/organizational perspective, as the imaging and biology. I've been trying to get computation-focused research on massive graph and activity analysis in this domain -- especially exploiting multiscale, multimodal integration of disparate imaging techniques and models -- picked up for 4 years now without success and am finally packing up and moving on out of frustration with the myopia of funding and priorities.