History says no. He was never able to build a great business with the fashionable blouses he designed. He never was able to scale his refrigerator company beyond the customer discovery phase and sold the patent to Electrolux... Google these if you think I am joking.

I found the patents for the blouses / refrigerators, but it seems to me that this was more of a hobby of his, not a serious startup endeavour.

My imaginary scenario is more like this: let's assume that there is something like the relativity theory of programming, i.e. in order to build programs of a certain size and complexity you HAVE to use the relativity theory, otherwise you'll fail. Now, could Einstein have built a software company that takes advantage of this?