Another way to attack a similar set of problems is through the new bundling and minification settings in .Net 4.5[1]. It doesn't address everything, for example you need to know and account for the dependencies yourself. However, my early experiences with using it have been very positive.
Good stuff! I was first exposed to AMD and Require.js through the Dojo Toolkit[1]. I'm a big fan of Ninject and IoC in general but for some reason it never occurred to me to apply those techniques to javascript. Our Dojo application is built on MVC3 and once it became fairly large I was glad to have learned about Require.js. :)
[1]http://weblogs.asp.net/scottgu/archive/2011/11/27/new-bundli...