The UK BBC tv programme "Horizon" had an episode called "Defeating the superbugs"[1]. (http://www.bbc.co.uk/programmes/b01ms5c6)

It had a great clip showing bacteria developing antibiotic resistance. They became so resistant that the antibiotics had reached the solubility level of the stuff they were using; they couldn't use more antibiotics because it wouldn't dissolve.

[1] Yes, the hyperbolic name is unfortunate.