I'm pretty sure the gtk dependencies weren't built by Astral, which, yes, unfortunately means that it won't always just work, as they streamline their Python builds in... unusual ways. A few months ago I had a similar issue running a Tkinter project with uv, then all was well when I used conda instead.
Yeah.. this is exactly the overall reality of the ecosystem isn't it? That being said I do hope uv succeeds in their unification effort, there's nothing worse than relying on a smattering of diff package managers and built streams to get basic stuff working. It's like a messy workshop, it works but there's a implicit cost in terms of the lack of clarity and focus for the user. It's a cost I'm not willingly paying.
It may not be the grand unifier if they aren't willing to compromise. Currently I'd say conda is the "grand unifier", giving users 100% what they ask for artifacts-wise, albeit rather slowly. On the other hand, uv provides things super fast, but those things may break 5% of the time in unusual ways on unusual configs. I have no issue using both for the fullest experience.
