My obvious need would be a version of "air display" that worked over usb, but when i looked into it 2 years ago talking over usb wasn't allowed except for certified products.
If you have a device that supports tethering, you can do that today. Turn on tethering, plug in the device, and they'll get a mini-LAN running over the USB connection.
If you have a WiFi-only device, or a cell plan that doesn't allow tethering, then this won't work, sadly.
So distribute it some other way. If it's a great app and lots of people have a use for it, they will find a way to get it. You have the greatest distribution channel known to man at your disposal which NO ONE, not even the mighty Apple, truly controls: the internet.
Apple is just one company... which happens to spend an inordinate amount of money on marketing and an incredible amount of effort trying to control people through the lure of nice form factor and a graphical interface.
But there's more to computing than form factor and GUI. Lots more.
(Over USB, specifically. Though WiFi might be workable for a game controller.)