I used to be on a chemo drug and had to take folic acid every day to stop it from doing bad things to me.
I had awful ulcers in my mouth from the chemo drug and had been taking the folic acid in the morning. Through forgetfulness I ended up shifting the folic acid to the afternoon and the ulcers went away and never came back.
And to think about how often such things are figured out individually, but go unnoticed, because there's basically 0 chance for the average person to get anyone to do a study on it.
My guess on some of this has to do with a few things. Hormone levels vary throughout the day along with immune system activity; My allergies are always worse in the morning than the day. I'm sure time is a huge component in a lot of medical things but I haven't personally seen any studies on this.
Most people also fast at night (sleeping) and are less physically active etc etc.
I had awful ulcers in my mouth from the chemo drug and had been taking the folic acid in the morning. Through forgetfulness I ended up shifting the folic acid to the afternoon and the ulcers went away and never came back.