The last two images you linked to are fake, and clearly designed by someone who doesn’t know Spanish and has never been to either Chile or Spain. No signs look like that in either country.
Nobody would dare capitalise “de” in Santiago de Chile for instance.
Confirming, the image linked by grandparent is tagged as 3d illustration on shutterstock[1]. A similar illustration with lowercase “de” spelling exists too[2]. Actual road signs in Chile have lowercase “de”[3].
Your last two links are fake. And you can check on your own Wikipedia link that for Spain's direction signs, only proper nouns are capitalized: full uppercase on conventional roads for historical reasons, otherwise the usual capitalization rules such as on highways or town roads. Whereas full lowercase is reserved for service directions (e.g. service road, airport, hospital, beach). The exceptional capitalized service directions are really old town signs.