One reason all space scientific instruments are not powered by RTGs is that prior to each launch NASA has to run a very involved and time-consuming risk analysis program to determine just how much of the state of Florida becomes uninhabitable for the next 10,000 years if the rocket blows up on the launch pad.
I had a Look Magazine cover from the early 1950s .. It showed oil barrels full of radioactive waste, with a guy moving one on a handcart, with heavy gloves on! The point of the photo was "radioactive material must be handled very carefully" .. the guy had thick gloves .. for a fifty gallon drum of radioactive waste, among many of them.. Things change
I used to conduct said risk analysis.