> But other than that, what's the issue with self-hosting Wireguard?

User simplicity. I am not the only one on my home network which I want to be able to access some parts of the things I build.

Device support. I appreciate that tailscale has gone out of their way to bring tailscale to even more devices than even wireguard supports. Namely apple tv, wireguard does support iOS but doesn't seem to currently support apple tv or maybe just my version of apple tv.