I never had much experience with scala.js. The nice thing with kotlin-js is that it's just kotlin. Thanks to Android, it's actually a good fit for UI development and a lot of the same libraries work in a browser as well. For example, we use koin for dependency injection, kotlinx serialization, ktor-client, coroutines, and a bunch of other stuff. We also use some npms. Stuff like maplibre and tailwind for example.

As for the compiled code. I spend about as much time looking at generated js as I do examining jvm byte code (none in case you were wondering). It's a compilation target. Yes it's ugly. But who cares? It actually goes through a mininification/uglification step as part of the webpack build. So, yes, it's going to be ugly.