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Ketosis occurs when your body switches from consuming glucose as its primary fuel source to consuming ketones which are generated from the breakdown of fatty acids, either from the diet or endogenous.

Almost all body tissue can run on ketones instead of on glucose, except for certain important tissues like red blood cells, 30% of the brain, retina, some kidney tissue, etc.

For the rest, your body synthesizes the glucose it needs via gluconeogenesis from some protein substrates and from glycerol backbodes from triglycerides. These inputs can be either from the diet or from your fat stores.

Fasting for a few days causes your body to enter authophagy through the inhibition of mTOR in addition to ketosis, so that could account for some of the difference.




Can you comment on the efficacy of intermittent fasting (IF) to get into ketosis? Does fasting have to be undertaken in the order of days in order to be any effective, as opposed to 16 or 18 hours per day by way of IF.

For context, I've been following IF for a couple of years. I can definitely see myself losing my resident body fat, which is encouraging. I had tried keto diet before that - I found it very difficult to sustain, especially when you're away from home or are at work. So, part of my motivation to do IF instead of keto is, well, that I can achieve some level of ketosis via IF, and without following a strict keto diet.


You can get into ketosis on any kind of diet or eating schedule, it mostly relies on avoiding dietary carbohydrates. If you're curious you can get ketone urine sticks, ketone breath tests and even a non-FDA-approved continuous ketone monitor (SiBio). IF can help because it gives you a long period without carbs so you're naturally getting less of them in a given period, unless you then load up on like white bread.

It's mostly a function of what you eat when you do eat.


Dr Thomas Seyfried, the guy in the Diary of a CEO interview, stated that intermittent fasting is beneficial and achieves the desired 'cell repair' effects.




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