Ha! Oh my, this is exactly what I am studying. MC1R is a G-Protein Coupled receptor (GOPCR) and the ARHGAP36 gene/enzyme is a GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Meaning it breaks down GTP (Guanosine Triphosphate is responsible for providing energy to the receptor.)
If there is too little or too much GTP it will effect the sensitivity of the MC1 Receptor and will change the color of the hair accordingly. BTW, humans have these same genes so the same will apply to humans.
I am studying these GPCRs and how they play a role in Mood and Chronic Illness like Long COVID and ME/CFS. Too little GTP and all of the 850+ G-Protein Coupled receptor will be effected. These include Serotonin, Dopamine, and Epinepherine Receptors.
I has an enzyme deficiency (PNP) that makes me have way too much GTP and it has me disabled but getting better after this discovery I made about Receptor Energy.
I too much GTP also leads to grey hair.
Also, GLP1 is a GPCR!
This might have been the most serendipitous or God given thing for me to read today because I have been pretty suicidal and thinking I was wrong about my idea, but this literally is another piece I can put in my paper that proves that if the serotonin receptor does not have enough GTP, it does not matter how much serotonin you have, you will not get cellular activation via cAMP.
Adding here that cats had more Arghap36 RNA in orange regions. More Arghap36 means less GTP. Less GTP means less energy for the MC1R receptor which means less black/brown pigment is produced.
I volunteer as tribute! I’m a 2003 PwME who is second generation, and my son is diagnosed 3rd generation. And we have lateral transmission to my wife, somehow. My Dx. was by Dr. Nancy Klimas 2009 and had an extensive work up by the Mayo in 2010. Seriously, if there is anything I can do to assist your research, please let me know. (I’ll put contact in my profile)
If there is too little or too much GTP it will effect the sensitivity of the MC1 Receptor and will change the color of the hair accordingly. BTW, humans have these same genes so the same will apply to humans.
I am studying these GPCRs and how they play a role in Mood and Chronic Illness like Long COVID and ME/CFS. Too little GTP and all of the 850+ G-Protein Coupled receptor will be effected. These include Serotonin, Dopamine, and Epinepherine Receptors.
You can see the whole list of them here: https://www.guidetopharmacology.org/GRAC/ReceptorFamiliesFor...
I has an enzyme deficiency (PNP) that makes me have way too much GTP and it has me disabled but getting better after this discovery I made about Receptor Energy.
I too much GTP also leads to grey hair.
Also, GLP1 is a GPCR!
This might have been the most serendipitous or God given thing for me to read today because I have been pretty suicidal and thinking I was wrong about my idea, but this literally is another piece I can put in my paper that proves that if the serotonin receptor does not have enough GTP, it does not matter how much serotonin you have, you will not get cellular activation via cAMP.
Adding here that cats had more Arghap36 RNA in orange regions. More Arghap36 means less GTP. Less GTP means less energy for the MC1R receptor which means less black/brown pigment is produced.