I have tried oxycodone (40 mg, went way above 80 mg too) and it did not make me high at all, people talk about a state of bliss and whatnot but I have never experienced it.
Most substances do not affect me the way they affect others; I have depression & anxiety and I have tried almost all antidepressants (along with mood stabilizers) to no effect.
I suspect it may have to do with my brain lesions (I have MS), but I am not quite sure.
That said, opiates do help with my physical symptoms, and only them, unfortunately.
> people like me need prescription strength (30-60mg) codeine to feel any benefits at all, and don't feel remotely high from it.
It is interesting though. Oxycodone is way stronger than codeine, and 80 mg is considered a very high dose yet it does not make me high, with or without tolerance.
My sister has defective P450 and your experience is the same as hers with opiates and other drugs, e.g. they are entirely ineffective when taken orally.
Most substances do not affect me the way they affect others; I have depression & anxiety and I have tried almost all antidepressants (along with mood stabilizers) to no effect.
I suspect it may have to do with my brain lesions (I have MS), but I am not quite sure.
That said, opiates do help with my physical symptoms, and only them, unfortunately.
> people like me need prescription strength (30-60mg) codeine to feel any benefits at all, and don't feel remotely high from it.
It is interesting though. Oxycodone is way stronger than codeine, and 80 mg is considered a very high dose yet it does not make me high, with or without tolerance.