In my view, prosecuting the bad actors alone will not fix science. Science is by its own nature a community because only a small number of people have the expertise (and university positions) to participate. A healthy scientific discipline and a healthy community are the same thing. Just like the "tough on crime" initiative alone often does not help a problematic community, just punish scientific fraud harshly will not fix the problem. Because the community is small, to catch the bad actors, you will either have insiders policing themselves, or have an non-expert outsiders rendering judgements. It's easy for well-intention-ed policing effort to turn into power struggles.

This is why I think the most effective way is to empower good actors. Ensure open debate, limit the power of individuals, and prevent over concentration of power in a small group. These efforts are harder to implement than you think because they run against our desire to have scientific superstars and celebrities, but I think they will go a long way towards building a healthy community.