I don't even have an xorg.conf. Things "just work", and if they don't, I use xrandr at the command line to fix things live. It's really gotten a lot better than the bad old days of hacking around with XF86Config.
Swapping xorg.conf for xrandr isn't a big win for most users. It is getting better, but things still fall apart like a sand castle when something goes wrong.
And even the command-line tool is far simpler than fiddling with xorg.conf. When I plug my laptop into its docking station, I run a little script to switch over to my two external monitors in portrait mode: