You don’t have to. I worked on data analysis (mostly cleaning and correction) for CMS (one of the two main experiments at LHC) for a while and didn’t have to touch it. Disclaimer: I was a high energy theorist, but did the aforementioned experimental work early in my PhD for funding.
I mean, most of the researchers I know at least use PyRoot (or the Julia equivalent) as much as possible, rather than actually interacting with Root itself. Which probably saves their sanity...
I did my master and PhD around the time numpy/scipy got competitive for a lot of analysis (for me a complete replacement) but the Python binding for root weren't there or in beta. Root-the-data+format remained however the main output of Geant4, so I set up a tiny Python wrapper around a root script that would dump any .root contents and load it up in a numpy file.
