I have had to do the same to fix Youtube progress reporting, but not much more. That is one of few things the PiHole has ever broken for me (that I know of...). I agree that a problem with PiHole is that if something is not working and I disable uBlock as a debugging step, then I have to also browse and login to 2 different PiHole GUIs and temporarily disable it. Without knowing if PiHole actually blocked anything. It is especially inconvenient when on the phone. I have not looked if it already exist, but I would want a nice little app I can open and just click "disable for X time" which would disable the blocking on all my PiHoles at once. Also syncing all settings from a "master" instance would be great. Maybe the default lists should contain some of the whitelis domains or something aswell.

Still, these problems are so small compared to the value I get out of my PiHoles. Blocking ads for years on end while having troubles maybe 3-4 times in total. All the other time it just works.