If you're interested in learning more about the challenges and tradeoffs, both Jython (https://www.jython.org/) and IronPython (https://ironpython.net/) have been around for a long time and there's a lot of reading material on that subject.
I've found the startup time for Graal Python to be terrible compared with other Graal languages like JS. When I did some profiling, it seemed that the vast majority of the time was spent loading the standard library. If implemented lazily, that should have a negligible performance impact.
