Things like vibration and Pogo oscillation (https://en.wikipedia.org/wiki/Pogo_oscillation). All the engines collectively have about twice the thrust of a Saturn S-IC first stage (on the Saturn V rocket) and they're all going to be trying to shake the crap out of each other just due to thrust oscillations. If they hit a resonant frequency of the rocket it could shake the rocket apart. So, you can have 33 engines that all individually ignite properly on the pad and are all well-built to tolerances so that they function, but when you put the whole vehicle together and have all 33 of them pushing against the same airframe they could spectacularly fail.