Nothing, but Brits had to quit their .eu domains due to Brexit. Which seems reasonable to me. Of course, Brexit wasn't; it was manipulated by the Russians.
Before .eu we had .eu.org where the country level was administered by so-called Good People (networking techies of the 90s), so you could have e.g. nl.eu.org this was for free. Back then (end 90s) I didn't envision UK leaving EU. I'm from NL, and I cannot envision NL leaving EU either.
But either way I agree with another comment you're better off with a ccTLD of the country where you were born and/or are residing. Though if I were born in Russia and were residing in USA I wouldn't want a .ru domain (unless if I were running a criminal enterprise?). At least not now. I do think it would be cool to own a .su domain. But that's the thing. Cool, not for anything serious. This was cool in the beginning of the internet, with a fun play e.g. on your last name (gongri.jp comes to mind). But nowadays with the internet being deeply rooted into our every day lives, it is no longer the most clever thing to do. Although as a Dutch person, I wouldn't be particularly worried about a .jp domain. We're on friendly terms.
