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Let's take fentanyl for example. It kills so many people that there isn't any good reason for it to be a legal drug off prescription.

The difference between fentanyl and other drugs is a matter of degree.



But the only reason fentanyl is a prevalent recreational drug is prohibition.

Heavy users vastly prefer heroin, casual users much prefer oxy or similar. Fentanyl is just cheaper to obtain and easier to traffick.

Furthermore a lot of fentanyl deaths are caused by mislabeling and misidentification of the drugs which would not happen without prohibition. Fake painkiller pills with fent in them, fentanyl poorly mixed into heroin or filter, etc.




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