Not sure I understand. Zram allows you to store pages in a compressed fashion to memory to prevent or at least delay until the OOM kicks in and to keep hold of cached files for longer to prevent needless disk reads. Considering the tradeoff is a marginal amount of CPU resources it seems like free extra space and a no-brainer to enable if swap on disk isn't desired, at least in my mind.

I remember having issues with system starvation if it started to make excessive use of zram but that has been pretty much levitated with the introduction of MGLRU.