With customization through Oryx, I've been able to make Ergodox / Moonlander quite amenable to many games that use MKB, especially those that make use of number keys, such as MMOs, by overlaying 1-5+macro with various combinations of double taps, holds, and tap-holds to represent 1-0-= and C-_ variants. So while it takes some customization, you can make such keyboards quite tractable for single-handed modes for individual pieces of software or for general use, with practice.