I have heard from some people that many companies specifically ask for your github profile, in many places only the user tag, not a link which can be changed to gitlab or something else.
So it will effect your job chances, even if the job has nothing to do with managing GitHub.
Thankfully that hasn't happened for me, yet. Or maybe that could be my own selection criteria - an active GitHub account should not be a prerequisite to get any type of computer job. If the hiring manager is serious about me, they can find the URL in my GitHub profile.
So it will effect your job chances, even if the job has nothing to do with managing GitHub.