If you boost into empty space (and not say the Magelanic Clouds or something similar) you are loosing access to a lot of usable mass. Maybe better to do a lot of backups and stay in the galaxy ?
Magellanic clouds are even more hazardous than where we are.
If you bring the solar system along, you have that; I assume you accelerate slowly enough to bring along the Kuiper Belt. It will take a long time before you need to start thinking about dismantling Jupiter.
If you solve the p-11B fusion problem (maybe you invent a mirror for x-rays?), you don't need the sun anymore, and may pick up and move operations to another solar system that is already moving off-disc at a good clip. You can bring along rotating cans of bio-stuff if you still use it (or anyway keep it as pets).
The new solar system can have a dead-ish star so the planets are frozen and convenient to mine for volatiles.
