It's hard enough to design a good game when the only constraint is that it has to be fun. Designing a fun game that also covers an entire year of calculus requires a stroke of genius. You have to find the fun that is inherent in the subject. Unless you're the type of person who just naturally finds calculus to be fun, it's unlikely you ever will.

There are games that find fun in seemingly mundane things, like parking or washing windows, but these are very simple things. And even then, the game takes many liberties with realism in order to make them fun.