Yes, it matter. Would we remove the brake pedal of a car while driving? This is the same idea.
We are talking about removing the main wire of entire ecosystems without a clue of the real outcome. Could have some benefits? yes, it could, but the nice extra space for the feet wouldn't worth the danger. An unfixable waterfall of problems and many local economical collapses would be guaranteed.
Why? An organism that causes millions of human deaths needs to be wiped out. This is an evolutionary imperative. If a species (humans) get out-competed to death at large scale it will go extinct.
We are talking about removing the main wire of entire ecosystems without a clue of the real outcome. Could have some benefits? yes, it could, but the nice extra space for the feet wouldn't worth the danger. An unfixable waterfall of problems and many local economical collapses would be guaranteed.