I mean if you don't want to fiddle with it I really don't get why you would choose Guix to test drive this way of managing your packages. It's the way less mature and less supported Nix.
Not when it comes to R. I'm terribly biased, but R packaging in Guix is --- in my opinion --- very high quality, purely from source (including bundled minified JavaScript), and the tooling is great too.
Unlike R in Nix, Guix does not just automatically wrap R packages, which would lead to build and runtime errors. I would not use R from Nix.
