I'm not so sure. say that Planned Parenthood operates shuttles to abortion clinics out of state. then Mississippi makes it a crime to operate any business within the state that facilitates abortion.

that would have an indirect effect on interstate commerce, but I could imagine the Court upholding Mississippi's ban, since it only concerns businesses that operate there.

of course, this would run straight into the Heart of Atlanta Motel decision that ended racial discrimination in hotels.