It tends to make the code pretty ugly.

There are ways to improve things somewhat (moving "bundles" of classNames into properties of a local or global cssClasses object and adding those to your elements' className), but you lose the intellisense when editing classes and it often ends up feeling like the extra friction isn't worth it. Having the styles right there seems to be a key part of what makes using tailwind so productive.

We have enough decisions to make regarding design as it is, adding organization, naming, selection, and attempting to maintain a sensible hierarchy into the mix leads to a fog of decision fatigue that I didn't realize existed until I tried Tailwind and it lifted.