A placebo control group when there is an established standard of care? That sounds highly unethical. The above link to the abstract don't mention this and I don't have access to the full text paper. If you do can you clarify what the control arm received?
I intentionally avoided using placebo group. The control cohort may not have had cancer at all
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The plan is to enroll six patients with MSI, regardless of their primary cancer diagnosis. This cohort will serve to generate hypothesis and initial data to plan a larger study. All analyses from this cohort will be exploratory
I appreciate your good intentions, but you should consider not writing things on the internet like this - as both of your posts are effectively misinformation.
> As with most experiments
This isn't true. It's absolutely standard in earlier trials of investigational agents to not have any sort of control arm.
> there's a control group (6 patients).
This isn't true. Within the study you posted, there are two different cohorts, with different patient types included.
> The control cohort may not have had cancer at all
This isn't true. The group you're calling a control cohort (cohort 2) must all absolutely have cancer, and are all actively treated with the study drug (TSR-042).
I’d encourage comment OP to continue writing comments online, so that you can learn. The damage done in misinformation here is probably extremely limited.
If comment OP was trying to misinform on purpose, it’s a different story as there’s no opportunity for improvement there.
