Skill would win out, but "hours" is not even the right ballpark.
For comparison, 50K hands is a standard length for heads up matches between pros, with the understanding that even then the best player is not guaranteed to win. In live play, you'd be looking at 50-100 hands per hour.
It's true that with a greater skill gap you'd need less time, but you'd still be looking at thousands of hands if you wanted something like 95% confidence that the better player was up.
For comparison, 50K hands is a standard length for heads up matches between pros, with the understanding that even then the best player is not guaranteed to win. In live play, you'd be looking at 50-100 hands per hour.
It's true that with a greater skill gap you'd need less time, but you'd still be looking at thousands of hands if you wanted something like 95% confidence that the better player was up.