A. Research dates back to the 90s. Thousands of researchers have added their perspectives.
B. Look at what vasopressin does, in humans and other mammals.
C. Consider that Vasopressin Receptor 2, is right by the X pseudoautosomal region, so is mutated 15x-20x more frequently. Compare how often you've seen other pseudoautosomal differences in people with Vasopressin transcription differences.
Or just start searching for random genes from around the pseudoautosomal region + autism. Transcription differences in one pseudoautosomal gene are so closely tied to differences in others, you see a very unusually high number of correlations between autism-uninvolved genes and autism.
(Just as so many genes around TNF-alpha/6p21.3 are spuriously tied to autoinflammatory issues; major histocompatibility complex issues; tenascin-X-tied disorders including Ehlers-Danlos; and 17-hydroxysteroid-dehydrogenase-8 variance [which deactivates androgens+estrogens, and synthesizes moderate estradiol].
Or how so many genes near the adjacent corticotropin-releasing-hormone-receptor-1 (CRHR1) and Tau protein (MAPT), in the same area as DNA-repair-gene breast-cancer-associated1 (BRCA1), are spuriously tied to irrecoverable oxidative cell damage and neurodegeneration.)
C...Some very important pseudoautosomal genes include the final stage of melatonin synthesis (ASMT & ASMTL); antiviral and anti-small-pathogen signal receptors, for interleukin 9 and interleukin 3; SPRY3 lymphoid-to-myeloid switch granulocyte-macrophage colony stimulating factor (GM-CSF); cytokine-like-receptor 2 (CLRF); glycogenin 2 (starting-point for muscle fibers); steroid sulfatase (activates androgens, estrogens, progestogens); sex receptor Y and protocadherin-11-Y (PCDH11Y) in men [causing heritable father-to-daughter changes in protocadherin-11-X and near-adhacent androgen receptor].
D. Also, check out the research from the last head of the Kinsey Institute. They hired her for that vasopressin+oxytocin triggers pair-bonding, and monogamy in monogamous mammals.
B. Look at what vasopressin does, in humans and other mammals.
C. Consider that Vasopressin Receptor 2, is right by the X pseudoautosomal region, so is mutated 15x-20x more frequently. Compare how often you've seen other pseudoautosomal differences in people with Vasopressin transcription differences.
Or just start searching for random genes from around the pseudoautosomal region + autism. Transcription differences in one pseudoautosomal gene are so closely tied to differences in others, you see a very unusually high number of correlations between autism-uninvolved genes and autism. (Just as so many genes around TNF-alpha/6p21.3 are spuriously tied to autoinflammatory issues; major histocompatibility complex issues; tenascin-X-tied disorders including Ehlers-Danlos; and 17-hydroxysteroid-dehydrogenase-8 variance [which deactivates androgens+estrogens, and synthesizes moderate estradiol].
Or how so many genes near the adjacent corticotropin-releasing-hormone-receptor-1 (CRHR1) and Tau protein (MAPT), in the same area as DNA-repair-gene breast-cancer-associated1 (BRCA1), are spuriously tied to irrecoverable oxidative cell damage and neurodegeneration.)
C...Some very important pseudoautosomal genes include the final stage of melatonin synthesis (ASMT & ASMTL); antiviral and anti-small-pathogen signal receptors, for interleukin 9 and interleukin 3; SPRY3 lymphoid-to-myeloid switch granulocyte-macrophage colony stimulating factor (GM-CSF); cytokine-like-receptor 2 (CLRF); glycogenin 2 (starting-point for muscle fibers); steroid sulfatase (activates androgens, estrogens, progestogens); sex receptor Y and protocadherin-11-Y (PCDH11Y) in men [causing heritable father-to-daughter changes in protocadherin-11-X and near-adhacent androgen receptor].
D. Also, check out the research from the last head of the Kinsey Institute. They hired her for that vasopressin+oxytocin triggers pair-bonding, and monogamy in monogamous mammals.
e.g. "Oxytocin and Vasopressin Circuits in Context of Love and Fear", from the 'Vasopressin System in Behavior' edition of Frontiers in Neuroendocrinology: https://www.frontiersin.org/articles/10.3389/fendo.2017.0035...
"Opposite effects of oxytocin and vasopressin on the emotional expression of the fear response" https://www.sciencedirect.com/science/article/abs/pii/S00796...
Dune's Fremen are stellar thought-experiments of vasopressin-driven folks who feel strong oxytocin boosts in their own homes/territory.