When cities are designed around cars, you must have a car to participate in society. As a result, it's a significant tax on the poor. The recent oil price spike has caused many people to worry about being able to afford to work.
That's a whole separate topic: Americans are like "just drive" and a large chunk of them just hate the poor for not having enough money to have and maintain a car.
But what about the people who actually can't drive? Epilepsy, vision, etc. There are a ton of reasons. But like what do these people do? There are so few places you can live without a car in the US compared to any other country on Earth.