I believe it was in his commencement address that he said something to the effect of, there will be days when you look in the mirror and have to say, I don't want to work today. But you do anyway. But if there are enough of these days in a row, you know you need to make a change.
I've left two very well paying positions (one at a very reputable design company that designed some of the early Apple & NeXT products) in the past year because I did look in the mirror and realized they were not right for me.
You have to follow your passion, back it up with action, and everything else will fall into place.