It's particularly damning once you begin to age. To pull a number out of my ass and give a piece of advice we all should focus on reducing mTor by 40.

David sinclair has a bunch of great material on the subject. On his own youtube channel, in talks with others.

David Sinclair is right about mTor and IGF-1 but i find him to be really untrustworthy.

he has so much riding on Resveratrol and has put so much into videos, books, gotten grants and so forth, that when studies came out proving Resveratrol isn't the miracle substance he (and many others) purported it to be, he basically just started doubling down and refusing to engage with other scientists calling him out on it.

if you have some time here's a good break down of what's transpired as it's escalated into a bit of social media drama:

May 2021: https://youtu.be/vpxQoGk_ryg

Jun 2021: https://youtu.be/K_dOJbplTxw (kind of reviews the previous video).

Aug 2021: https://www.youtube.com/watch?v=e7u6esW3qVw&t=124s

Oct 2021: https://www.youtube.com/watch?v=nXC9W7st9B4

March of 2022: https://www.youtube.com/watch?v=pLWQKMEXmuY

David Sinclair also will site highly biased sources if they re-affirm his existing premise. For example, he's been increasingly vegetarian and vegan over the years (and hey - they're good evidence backing up that less meat is mostly a positive).

But he'll site things like Adventist studies on a regular basis.

These studies are shit b/c they're observational

But they're shit moreso because Adventists are vegetarian as a matter of religious faith.

That's their whole angle. They're not going to produce anything that contradicts that worldview.

In fact, Adventists are founders of companies like Kellogs and they're responsible for peddling bad science for decades, like the Ancel keys Seven Nations study that left out countries to make up a bullshit conclusion about Saturated Fats that simplly didn't exist in the data.

This has shaped national nutrition policy and advice for decades. All so they can keep pumping processed products and PUFA's to the public to enrich corporations founded on their religious values.

So to site them, when they aren't doing hard science and trying to use your credentials as a scientist to validate it.. is just bullshit.

Sinclair gets a lot of stuff right but i wouldn't trust him as far as you could throw him.

he doesn't have an alliance to facts anymore. he has his self-interest and his worldview and everything else has to conform to it.

> Resveratrol

That's a pretty outdated view of him. I've seen him admit resveratrol was thematically the right idea, but admittedly not as revolutionary as hoped. Lately he's been more interested in sirtuins, NMN and the like as ways of dealing with the 4 yamanaka factors etc.

I highly recommend his youtube channel where he puts it into pretty easily consumable content

i cannot delete my comment.

But scratch that, he actually seems to be recently digging in trying to claim still being right about resveratrol (:sad_panda:).

Thanks for sharing those links giving a more balanced view.