Thank you for your optimism, now let me balance that out a little.
Propulsion maybe the easier part of engineering. Afaik we are nowhere near to life support and environment control that could be considered stable for a time period of maybe 10 years or more.
The biggest biological advantage, adaptation is meaningless for large organism on such a timescale and maybe dangerous on a microbial level.
You are correct that we are nowhere near that in life support technology, however, there don't seem to be an fundamental hurdles there. If we end up opting for a biological life support system, adaptation would not even enter the equation - it'd be a matter of genetic engineering. An obvious danger would always be onboard ecosystem collapse, of course.
Propulsion maybe the easier part of engineering. Afaik we are nowhere near to life support and environment control that could be considered stable for a time period of maybe 10 years or more.
The biggest biological advantage, adaptation is meaningless for large organism on such a timescale and maybe dangerous on a microbial level.