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It seems virtually all stimulants used as a crutch to counter anxiety, depression, physical pain etc wind up killing off a lot of brain cells. My concern with modern (incredibly strong) Cannabis/THC is that some regular users seem to struggle with withdrawal if they don't smoke their bowls regularly, run short on weed etc.



Near daily smoker, these days pretty exclusively of the high potency stuff.

I've quit cold turkey multiple times for a variety of reasons, sometimes for 6+ months at a time. I've never noticed any withdrawal symptoms, thankfully. Or cravings on days/weekends/whatever where I don't smoke.

It's anecdotal experience, obviously, but it leads me to believe that there's not some near-universal withdrawal process that pot smokers go through that you would see with someone who is going through opiate withdrawal or similar.


I believe it ends up why one was smoking (or using any substance in any way) in the first place.

If you're enjoying and it just becomes a (not super healthy-but not my point here) everyday habit, sure, you probably won't have withdrawal symptoms.

If you're using something to get away from some reality in life that is too unbearable, and that unbearable thing is still a matter when you want to quit, then it'll be hard. But it's not actually the substance (excluding hard/chemically super addicting class of substances like heroin or sugar) but the fact of facing the problems.


Weed withdrawals can be very hard. I had to borderline force feed myself in the past right after quitting because my appetite was dead. You’re insomniac as hell, tired, irritable, and just generally uninterested


Weed withdrawals can last months for me, severe depression / anhedonia / executive function impairment; duration depending on how much/long I used.

I'll bounce back but man does it suck going through the repair process. Nothing is enjoyable, life just feels dull and flat, and it's hard to get anything done.


I don't know anything about you other than the two sentences that you just wrote up there, but I've known other people who have expressed similar sentiments. After years of struggling with this, they've determined that what's actually going on is that they in fact are depressed and have been for years, and their cannabis use has basically been self-medication of an anti-depressant. They thought it was cannabis withdrawal that was causing these symptoms, but what's actually been going on is that they were stopping treatment that was working (for other reasons, like "I don't want to be a stoner forever" or something)

They also reported the "bounce backs" as you do, but those were never permanent.

You have no reason to take this advice from someone random on the Internet, but I strongly recommend that you get yourself evaluated for depression or something related.


> but what's actually been going on is that they were stopping treatment that was working

Hard disagree. Cannabis isn’t actually an anti-depressant in the same way that alcohol and other euphoric drugs aren’t antidepressants. Chronic cannabis use has also been correlated with increased depression scores over time.

But that’s beside the point: Cannabis withdrawal and rebound is a very real phenomenon. It’s another myth that you can’t get addicted to THC or that it’s okay because it’s not a “physical” addiction. The withdrawal effects described above are consistent with cannabis withdrawal syndrome and are well documented.


There is ample research that cannabis functions as an anti-depressant. https://scholar.google.com/scholar?q=cannabis+as+antidepress...

There are many caveats that go into posting a Google Scholar link - the quality of the research is unknown, there is the reproducibility crisis to worry about, etc. etc; However, the presence of this ample research means that "Cannabis isn't actually an anti-depressant" is far from settled, and you shouldn't be stating that with such confidence.

Edit: Also, I happen to agree with you that cannabis withdrawal and rebound are real, and I agree with you that it is possible to get addicted to THC, and, sure the effects described above are consistent with cannabis withdrawal. None of that contradicts what I wrote.

However, those effects are also consistent with anti-depressant self-medication, and, as I mentioned, I've known people who went on prescribed anti-depressants, stopped having those effects and have had a marked improvement in their quality of life. (Some continued using cannabis, some stopped; it didn't seem to matter afterwards). I thought it was important to share that anecdata. I was very careful in my message to not say "you don't have cannabis withdrawal"; I was trying to communicate that I knew people that sounded like basq and it turned out they were diagnosed with clinical depression. Basq could have either outcome.

So, yea, sorry - hard disagree with your level of confidence.


Most of those top links are for cannabidiol, not cannabis. One of the top results clearly says that scant research suggesting that cannabis is an antidepressant is lacking in quality.

Your link doesn’t even begin to support your claims.


Literally first title:

"Antidepressant-like effect of Δ9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L."

And yes, the majority of the claims are that CBD is the anti-depressant; self-administration of CBD comes primarily from smoking/vaping/ingesting cannabis, so I don't even understand what "cannabidiol, not cannabis" means.

I don't really get the impression that you are arguing in good faith here, especially the "Please respond to the strongest plausible interpretation of what someone says, not a weaker one that's easier to criticize." part of HN guidelines, so I'm just gonna drop this thread now.


> Chronic cannabis use has also been correlated with increased depression scores over time.

As someone diagnosed with depression long before ever partaking in cannabis, this doesn’t surprise me at all. People with depression seek relief, and cannabis can provide that to an extent.


Yes, it’s a common theme with any drug known to cause short-term euphoria: People will confuse the drug-induced euphoria for anti-depressant effect, but they’re very different.


The subreddit r/leaves has been really helpful for me in the past


The punny name of the sub and the reference to r/trees is lovely.

Knew r/trees but didn't know r/leaves.

Thanks.


You’ll like what r/MarijunanaEnthusiasts


That is not withdrawal. That is a preexisting condition.


Why do you mean?


I think they are implying OP has used weed as a crutch and accidentally obscured a real condition.

A bit like using painkillers to avoid having knee surgery. A crutch, not a solution.


And that is why you should only take one or two puffs and not smoke a whole joint like 15 years ago. Also, I'm strongly convinced you should not be consuming it everyday, maybe 3 times a week max and even then that is hectic. People are way to chilled out about cannabis/thc dosages.


I think people "should" be consuming whatever they want. We're not free if we're not free to damage or destroy our own damn selves. It's really nobody else's business what goes into one's own body, or how damaging it is or is not to the person ingesting it.


Well, maybe, but I think the parent comment had implicitly meant "should... [if you want to avoid cognitive impairment" rather than making any moral judgement on those who don't.


Mmm sounds like American individualism. You do not live in isolation and nothing happens in isolation. Everything we/you do affects others. Freedom is a false carrot that's been used to make people feel good enough so they don't burn down their governments when things go wrong. Stop paying rates/taxes and see how free you are.

Every single person who end up in EC/ER due to drugs/alcohol/jumping off roofs, are a drain on society. Yes it great that we can fix those people up when they hurt themselves, but where is the line when people get reckless etc? Someone is paying to get your broken leg fixed. We all need to acknowledge that and appreciate one another. Every hour that I work, someone in my country gets fed by a government grant, all I ask is that the person take care of themselves and not waste my money.


> Mmm sounds like American individualism.

Having rights to one's own physical body has nothing to do with America.

If we don't have ultimate physical control over our own physical body, to do with it as we please, we can't really be said to have any meaningful rights at all. All other basic rights as an existing entity stem from the fact that we are ourselves, and others are not.

It's absolutely not individualism to say that every adult human being should have unrestricted rights over their own person-as-object, to enrich or damage as one sees fit. That seems plain as day to me. How can you even have the concept of a society of people if the societal group claims ownership rights over the bodies of the people that supersede those of the people themselves?

(If you think society shouldn't be spending money to repair damage caused by individual choices because it's unfair, we're in agreement there, but your broken leg case is a bad example, because you end up illustrating a point which I don't think you meant to make: that healthcare costs, something extremely variable based on individual choices, probably shouldn't be borne by society as a whole but by individuals themselves.)


> How can you even have the concept of a society of people if the societal group claims ownership rights over the bodies of the people that supersede those of the people themselves?

Uh... how can you have the concept of a body of cells if the body claims ownership over the entirety of each one of it's cells?

Did you stub your toe? Well it's not actually, your toe, it's an independent living organism, and you need to respect it's God given right to run into hard objects every now and then.

Really though, I think if you explore the wide variety of human cultures that have existed over time, you'll find that historically speaking, the default level of organization has been the tribe, not the individual. Indeed, individualism as we know it is only possible in highly organized societies, with super-powerful governments that create a monetary system, common language, infrastructure, legal and judicial system to enforce contracts, and other things that enable one to live "independently" like Ebenezer Scrooge.

For a right-wing take on this, please see "The Rational Optimist" by Matt Ridley. If you prefer a more moderate view, I recommend "Better Angels of our Nature" by Steven Pinker. Finally, the book "Debt, the first 5000 years" by David Graeber touches on more than a few of these topics.

Granted, I may be misunderstanding your argument, so please clarify if this is the case. :)


Sure, if it doesn't affect anyone else. Sadly that's not always the case, e.g. if you are prone to psychotic episodes from consuming said thing or just having society paying for your cancer treatment later on


Taking drugs doesn't affect anyone else. Having psychotic episodes doesn't affect anyone else. Doing already-illegal things that violate the rights of others during psychotic episodes, that affects other people.

Taking drugs doesn't affect anyone else. Getting cancer doesn't affect anyone else. Receiving cancer treatment doesn't affect anyone else. Using public funds to pay for that cancer treatment, that affects other people.

Those things should not be conflated, or treated as identical.


I wrote the parent comment and mostly agree with you about personal choice @sneak, except 'Taking drugs doesn't affect anyone else'. Whether alcohol, weed, opiates or whatever substance abuse is hugely costly and damaging in modern society to those who don't have this disease. There is a strong argument for pre existing substance dependency condition in people but the toll on those around them is huge.

You are smudging cancer and substance abuse together but in many cases complete abstinence in an individual due to awareness of a pre existing familial susceptibility can help that person to never become addicted because they are aware of the danger and biological weakness in themselves. 12 step programs etc can help people abstain if they become addicted although it is a huge and heroic struggle back to the surface.

Sadly this is not the case with cancer.


Parent isn't doing anything more than suggesting users consider dosage and frequency. It's good advice IMO. Nothing was said about taking away your right to kill your own brain cells.


> It seems virtually all stimulants used as a crutch to counter anxiety, depression, physical pain etc wind up killing off a lot of brain cells.

First off, medications used to treat medical disorders aren't a crutch. Knock that off.

Second, this simply isn't true. "If it works well, it must be destructive" is the sort of zero-sum folk wisdom nonsense you find in backwaters. Stick to the facts.

Any thread about commonly used psychoactive drugs brings out all of these thinly-veiled attempts at moralization over others. :(


Not even alcohol (one of the "dirtiest" drugs as far as physiological effects go) kills brain cells. I wish this myth would die. The issue is in the way they affect your dopaminic and serotonergic regulation and how this can fuck up your brain chemistry, not that they're literally killing off your brain cells.

> My concern with modern (incredibly strong) Cannabis/THC is that some regular users seem to struggle with withdrawal if they don't smoke their bowls regularly, run short on weed etc.

That said, this is a very legitimate concern I have as well. It doesn't help that a lot of stoners seem like they're in denial over the fact that they gasp have a dependence on this substance like an alcoholic or smoker does.


Alcohol can kill brain cells, but from overactivity of withdrawals.

> Scientists postulate that this syndrome [Alcohol Withdrawal] represents the hyperactivity of neural adaptive mechanisms no longer balanced by the inhibitory effects of alcohol

> Increased NMDA receptor activity significantly increases the amount of calcium that enters nerve cells. Although calcium is essential for nerve cell function, an excess of this substance within neurons has been reported to produce cell toxicity or death

https://pubs.niaaa.nih.gov/publications/arh21-2/144.pdf


> struggle with withdrawal

Anecdata, but for big smokers they'll notice more cognitive decline for a couple of months if they quit abruptly.

Alcohol is even worse for teenager cognitive abilities, I don't believe weed is as harmful that it would produce as much neuronal damage.




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