That used to be a much bigger deal in the US back in 1975. Our house had a coal bin and a coal fired boiler at that point. Insulation was non-existent in many places.
With almost 50 years of construction differences, moving that thermostat saves much less energy nowadays.
What discomfort? My children and I go barefoot and T-Shirt while the rooms have 19°C.
They are slim and muscular, ideal BMI, so spare me any "fat isolates" comments.
Subjectively, I am chilly keeping my house at 19° than at 22°. Not sure if this is an effect of thermostat placement or Nest’s algorithm for hot water rad heat (True Radiant).
How about +13 while just wearing more clothes? That would do a huge impact on ecology. Maybe even save us another hundred or so years before global warming comes