Individual locales can have particular niche demands or simply end up as technical backwaters where employability depends entirely on your familiarity with, say VB 6.
That's mostly, I think, an argument for moving out of technical backwaters if you're in a technical career. If you let yourself be limited to skills that are more valuable in Minneapolis than the major tech hubs, you're eventually going to be stuck with skills that aren't even valuable in Minneapolis, as the "hot" tech hub technologies become mainstream and finally migrate there way out to the backwaters.
That's mostly, I think, an argument for moving out of technical backwaters if you're in a technical career. If you let yourself be limited to skills that are more valuable in Minneapolis than the major tech hubs, you're eventually going to be stuck with skills that aren't even valuable in Minneapolis, as the "hot" tech hub technologies become mainstream and finally migrate there way out to the backwaters.