Typing this right now a HoneyComb running Fedora 34. RX560 gpu, nvme, 32GB of DDR4 3000 XMP memory. Are there rough edges with Aarch64 on the desktop, sure but without platforms like HC this will never change. There are lots of core OSS devs using HC to help solve these problems. Here is a video presented at the last Linaro Connect https://www.youtube.com/watch?v=tloLT4EPSpo
So maybe it will work out of the box. That said the ARM ecosystem still seems immature on desktop.