If memory serves, some diseases can trigger something called Mast Cell Activation, which in effect...makes your body get allergic reactions to tons of things.
I HIGHLY recommend that, if it's in your budget, she make an appointment at the Center for Complex Diseases. They specialize in these sorts of issues. They are also really good at finding potential tick-borne coinfections such as Babesia and Bartonella. These are tricky to culture and they know which labs are best. I believe they are doing tele-health during Covid.
Note that the CCD is Not Cheap. While you can get insurance reimbursement for some of the doctor visits, it won't cover the whole thing. But I spent 10 years going to 'regular' doctors and I made more progress with them in 5 months than I did in the previous 5 years of medical appointments.
I mention co-infections because the treatment for Lyme (doxycycline) is not as effective with some coinfections. Like I think the treatment for Babesia is clindamycin + some form of quinine. It's a parasite that infects red blood cells, kind of like malaria. So one possibly out of many is your wife could have been treated successfully for Lyme, but still have an underlying active co-infection. That's why seeing the right doctors is so important.
Yeah, my spouse has something like this, and tracing it back, we realized that it all started when she went off a long-term doxycycline treatment for adult acne. We've been trying to get a doctor to get her a new prescription, but many have been cagey because it's an antibiotic and they don't want to have her develop an antibiotic-resistant strain of some other disease in the process. Honestly, I can't imagine it would be any worse than 10 years of a deteriorating life where she can no longer work, or do anymore physical exercise than casually walking 1/4 of a mile. (She was previously a professional dancer, so you can imagine the psychological toll this has had.)
I HIGHLY recommend that, if it's in your budget, she make an appointment at the Center for Complex Diseases. They specialize in these sorts of issues. They are also really good at finding potential tick-borne coinfections such as Babesia and Bartonella. These are tricky to culture and they know which labs are best. I believe they are doing tele-health during Covid.
https://www.centerforcomplexdiseases.com/
Note that the CCD is Not Cheap. While you can get insurance reimbursement for some of the doctor visits, it won't cover the whole thing. But I spent 10 years going to 'regular' doctors and I made more progress with them in 5 months than I did in the previous 5 years of medical appointments.