The GDP of the US last year was less than 21 trillion, and we're talking about fraud that's allegedly 400 billion. Ergo, we're talking about ~2% of GDP. That's not "chasing pennies."
To put that in different context, 400 Billion is about 4x as much as the federal government spends on education. It is about 15x what we spend on energy infrastructure.
400 billion is a 2% of GDP but >10% of the federal budget.