I've been using [1] which is SQLite compiled to WASM (what a weird world we're in now). It's got some limitations and caveats, but it's working well for my current modest needs. It's a pretty straightforward wrap of the SQLite API - no ORM. The advantage is that it doesn't depend on having anything installed. Just import and you're good to go.
I'd love to see a benchmark between using this and a natively compiled sqlite. Just to see how much performance is lost to this convenience, so I can judge if it would be worth it in a concrete project for me.
[1] https://deno.land/x/sqlite@v2.4.2